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Novel Chemo-enzymatic Oligomers of Cinnamic Acids as Direct and Indirect Inhibitors of Coagulation Proteinases by Bernhard H. Monien; Brian L. Henry; Arjun Raghuraman; Michael Hindle; Umesh R. Desai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Novel Chemo-enzymatic Oligomers of Cinnamic Acids as Direct and Indirect Inhibitors of Coagulation Proteinases about?
Thrombin and factor Xa, two important procoagulant enzymes, have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. Our efforts on exploiting the indirect mechanism led us to study a carboxylic acid-based scaffold, which displayed major acceleration in the inhibition of these enzymes [J. Med. Chem.2005, 48, 1269, 5360]. This work advances the study to chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids, DHPs, which display interesting anticoagulant properties. Oligomers, ranging in size from tetramers to pentadecamers, were prepared through peroxidase-catalyzed oxidative coupling of caffeic, ferulic, and sinapic acids, and sulfated using triethylamine-sulfur trioxide complex. Chromatographic, spectroscopic, and elemental studies suggest that the DHPs are heterogeneous, polydisperse preparations composed of inter-monomer linkages similar to those found in natural lignins. Measurement of activated thromboplastin and prothrombin time indicates that both the sulfated and unsulfated derivatives of the DHPs display anticoagulant activity, which is dramatically higher than that of the reference polyacrylic acids. More inter
Who reads Novel Chemo-enzymatic Oligomers of Cinnamic Acids as Direct and Indirect Inhibitors of Coagulation Proteinases?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bernhard H. Monien; Brian L. Henry; Arjun Raghuraman; Michael Hindle; Umesh R. Desai
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)