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Development of a Quadruple Imaging Modality by Using Nanoparticles by Do Won Hwang; Hae Young Ko; Suk-Ki Kim; Daehong Kim; Dong Soo Lee; Soonhag Kim is a Chemistry article available to read on EtoBox.

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## Abstract The combination of nanotechnology with molecular imaging has great potential for the development of diagnostics and therapeutics, and multimodal imaging enables versatile applications from cell tracking in animals to clinical applications. Herein, we report a multimodal nanoparticle imaging system that is capable of concurrent fluorescence, bioluminescence, bioluminescence resonance energy transfer (BRET), positron emission tomography (PET) and magnetic resonance (MR) imaging in vivo. A cobalt–ferrite nanoparticle surrounded by rhodamine (MF) was conjugated with luciferase (MFB) and __p__‐SCNbnNOTA (2‐(4‐isothiocyanatobenzyl)‐1,4,7‐triazacyclonane‐1,4,7‐triacetic acid) followed by ^68^GaCl~3~ (magnetic‐fluorescent‐bioluminescent‐radioisotopic particle, MFBR). Confocal microscopy revealed good transfection efficiency of MFB into cells and BRET was also observed in MFB. A good correlation among rhodamine, luciferase, and ^68^GaCl~3~ was found in MFBR, and the activities of each imaging modality increased dose‐dependently with the amount of MFBR in the C6 cells. In vivo optical images were acquired from the thighs of mice after intramuscular and subcutaneous injections o

Who reads Development of a Quadruple Imaging Modality by Using Nanoparticles?

Author

Do Won Hwang; Hae Young Ko; Suk-Ki Kim; Daehong Kim; Dong Soo Lee; Soonhag Kim

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0947-6539)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)