Question 1

What is Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim about?

Accepted Answer

The circadian oscillator generates a rhythmic output with a period of about 24 hours. Despite extensive studies in several model systems, the biochemical mode of action has not yet been demonstrated for any of its components. Here, the
__Drosophila__
CLOCK protein was shown to induce transcription of the circadian rhythm genes
__period__
and
__timeless__
. dCLOCK functioned as a heterodimer with a
__Drosophila__
homolog of BMAL1. These proteins acted through an E-box sequence in the
__period__
promoter. The
__timeless__
promoter contains an 18–base pair element encompassing an E-box, which was sufficient to confer dCLOCK responsiveness to a reporter gene. PERIOD and TIMELESS proteins blocked dCLOCK's ability to transactivate their promoters via the E-box. Thus, dCLOCK drives expression of
__period__
and
__timeless,__
which in turn inhibit dCLOCK's activity and close the circadian loop.

Question 2

Can I read Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim on EtoBox?

Accepted Answer

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim by Thomas K. Darlington; Karen Wager-Smith; M. Fernanda Ceriani; David Staknis; Nicholas Gekakis; Thomas D. L. Steeves; Charles J. Weitz; Joseph S. Takahashi; Steve A. Kay is a Medicine article available to read on EtoBox.

Question 3

Who reads Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim?

Accepted Answer

It is typically read by researchers, students, and practitioners in Medicine.

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About this Medicine article

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