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Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms by Shannon K. Bromley; Michael L. Dustin is a Immunology and Microbiology article available to read on EtoBox.
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## Summary Chemokines adsorbed to the cell surface play an important role in the initial interactions of T cells with endothelial cells, and may also have a role in T‐cell interactions with dendritic cells. Therefore, we examined the effect of surface‐adsorbed chemokines on the interaction of naïve murine splenic T cells with supported bilayers containing intercellular adhesion molecule (ICAM)‐1, or with bone marrow‐derived cultured dendritic cells in the presence and absence of relevant MHC–peptide complexes. Naïve T cells formed immunological synapses, defined as a ring of lymphocyte function associated (LFA)‐1–ICAM‐1 interactions surrounding a central cluster of MHC–peptide complexes, on supported planar bilayers containing ICAM‐1 and relevant MHC–peptide complexes. Chemokines stimulated an increase in the percentage of naïve cells that adhered to ICAM‐1, but did not increase the average number of LFA‐1–ICAM‐1 interactions in the contact area. In contrast, relevant MHC–peptide complexes resulted in a small increase in the proportion of interacting T cells, but stimulated an 8‐fold increase in the number of LFA‐1–ICAM‐1 interactions in each contact formed. Naïve T cells displayed
Who reads Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Shannon K. Bromley; Michael L. Dustin
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)
- Published
- 2002
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)