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What is Racecadotril for Acute Diarrhoea Treatment about?

Racecadotril is a prodrug used to treat acute diarrhea that is hydrolyzed to the active metabolite thiorphan. Unlike loperamide, racecadotril does not act on opiate receptors but instead inhibits the enzyme responsible for breaking down endogenous opioid peptides that reduce fluid secretion. By inhibiting the breakdown of enkephalins, thiorphan enhances their antisecretory effects on epithelial cells through delta opiate receptors. Racecadotril is rapidly absorbed and converted to thiorphan, which does not

Author

Lindsay Grace Mandario

Language

EN