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CD4+ T lymphocytopenia with disseminated HPV by Cloyce L. Stetson; Ronald P. Rapini; Stephen K. Tyring; Robert C. Kimbrough is a Medicine article available to read on EtoBox.

What is CD4+ T lymphocytopenia with disseminated HPV about?

**Background:** There have been several reports of HIV‐negative patients with chronic idiopathic CD4+ T lymphocytopenia, the diagnostic criteria for which are: depressed numbers of circulating T lymphocytes (less than 300/μl or less than 20%) on more than one occasion; no laboratory evidence of HIV‐1 or HIV‐2 infection; and the absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+ T lymphocytes. **Methods:** We report a patient with disseminated human papillomavirus infection associated with idiopathic CD4+ T‐cell lymphocytopenia. A 50‐year‐old woman presented to the dermatology clinic with a 10‐year history of widespread verrucae involving the skin and the cervix. **Results:** Biopsy from the arm revealed a common wart. PCR analysis performed from the paraffin‐embedded block was strongly positive for HPV type 2. Other HPV types (including EV‐associated HPV 5, 8, 14, 15, 17) were not found. Further laboratory work up revealed T‐cell lymphocytopenia, with an absolute CD4 count of 21. HIV tests were repeatedly negative. She was treated with interferon A 8 million units SQ three times per week with partial improvement. The patient underwent a hyst

Who reads CD4+ T lymphocytopenia with disseminated HPV?

Author

Cloyce L. Stetson; Ronald P. Rapini; Stephen K. Tyring; Robert C. Kimbrough

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)

Published

2002

Language

EN

Field

Medicine (Health Sciences)