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Voltage‐dependent K^+^ channel β subunits in muscle: Differential regulation during postnatal development and myogenesis by Maribel Grande; Elisabeth Suàrez; Rubén Vicente; Carles Cantó; Mireia Coma; Michael M. Tamkun; Antonio Zorzano; Anna Gumà; Antonio Felipe is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Voltage‐dependent potassium channels contribute to the electrical properties of nerve and muscle by affecting action potential shape and duration. The complexity of the currents generated is further enhanced by the presence of accessory β subunits. Here we report that while all Kvβ mRNA isoforms are present in rat brain, muscle tissues express only Kvβ1 (Kvβ1.1–Kvβ1.3) and Kvβ2, but not Kvβ3. Kvβ subunits were close regulated through post‐natal development in brain and striated muscle, as well as during myogenesis in the rat skeletal muscle cell line L6E9. While the alternatively spliced Kvβ mRNA products from __Kvβ1__ gene were differentially expressed, Kvβ2.1 was associated with myogenesis. These results show that Kvβ genes are strongly regulated in muscle and suggest a physiological role for voltage‐gated K^+^ channels during development and myotube formation. © 2003 Wiley‐Liss, Inc.

Who reads Voltage‐dependent K^+^ channel β subunits in muscle: Differential regulation during postnatal development and myogenesis?

Author

Maribel Grande; Elisabeth Suàrez; Rubén Vicente; Carles Cantó; Mireia Coma; Michael M. Tamkun; Antonio Zorzano; Anna Gumà; Antonio Felipe

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)