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The effect of nicotine on striatal dopamine release in man: A [^11^C]raclopride PET study by Andrew J. Montgomery; Anne R. Lingford‐Hughes; Alice Egerton; David J. Nutt; Paul M. Grasby is a Neuroscience article available to read on EtoBox.

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## Abstract In common with many addictive substances and behaviors nicotine activates the mesolimbic dopaminergic system. Brain microdialysis studies in rodents have consistently shown increases in extrasynaptic DA levels in the striatum after administration of nicotine but PET experiments in primates have given contradicting results. A recent PET study assessing the effect of smoking in humans showed no change in [^11^C]raclopride binding in the brain, but did find that “hedonia” correlated with a reduction in [^11^C]raclopride binding suggesting that DA may mediate the positive reinforcing effects of nicotine. In this experiment we measured the effect of nicotine, administered via a nasal spray, on DA release using [^11^C]raclopride PET, in 10 regular smokers. There was no overall change in [^11^C]raclopride binding after nicotine administration in any of the striatal regions examined. However, the individual change in [^11^C]raclopride binding correlated with change in subjective measures of “amused” and “happiness” in the associative striatum (AST) and sensorimotor striatum (SMST). Nicotine concentration correlated negatively with change in BP in the limbic striatum. Nicotine h

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Author

Andrew J. Montgomery; Anne R. Lingford‐Hughes; Alice Egerton; David J. Nutt; Paul M. Grasby

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2007

Language

EN

Field

Neuroscience (Life Sciences)