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Does Cholesterol Discriminate Between Sphingomyelin and Phosphatidylcholine in Mixed Monolayers Containing Both Phospholipids? by Peter Mattjus; J.Peter Slotte is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Does Cholesterol Discriminate Between Sphingomyelin and Phosphatidylcholine in Mixed Monolayers Containing Both Phospholipids? about?
The objective of this work was to examine the interaction of cholesterol with both phosphatidylcholines, l-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine IDPPC), and sphingomyelins, N-oleoyl-D-sphingomyelin (O-SPM) or N-palmitoyl-o-sphingomyelin (P-SPM), in monolayers at an air/water interlace. We used cholesterol oxidase to probe for the relative strength of sterol-phospholipid interaction, and fluorescence microscopy to visualize lateral domain formation in the mixed monolayers. The ternary mixed monolayers, which contained cholesterol, POPC, and O-SPM had a twofold higher average oxidation rate than the corresponding system containing DPPC and P-SPM. This difference in oxidation rate between saturated and unsaturated systems was observed irrespective of the ratio between phosphatidylcholine and sphingomyelin in the monolayer. With either the saturated or the unsaturated systems, however, the rate of oxidation was influenced by the ratio of phosphatidylcholine to sphingomyelin. As the monolayer content of phosphatidylcholine increased and the sphingomyelin content decreased correspondingly (to maintain a constant cholesterol-t
Who reads Does Cholesterol Discriminate Between Sphingomyelin and Phosphatidylcholine in Mixed Monolayers Containing Both Phospholipids??
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Peter Mattjus; J.Peter Slotte
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)
- Published
- 1996
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)