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Can I read Transfusion-related Acute Lung Injury Due to Granulocyte-agglutinating Antibody in a Patient with Paroxysmal Nocturnal Hemoglobinuria on EtoBox?
Transfusion-related Acute Lung Injury Due to Granulocyte-agglutinating Antibody in a Patient with Paroxysmal Nocturnal Hemoglobinuria by B. Żupańska; M. Uhrynowska; L. Konopka is a Medicine article available to read on EtoBox.
What is Transfusion-related Acute Lung Injury Due to Granulocyte-agglutinating Antibody in a Patient with Paroxysmal Nocturnal Hemoglobinuria about?
BACKGROUND: Transfusion‐related acute lung injury (TRALI) is usually reported after the transfusion of blood components from donors with white cell (WBC) antibodies, but only very rarely if the patient has these antibodies. The pathogenesis of TRALI is not fully understood. Not all transfusion recipients develop TRALI, even though WBC antibodies are present in the donor or the recipient. CASE REPORT: A patient with paroxysmal nocturnal hemoglobinuria (PNH) who developed TRALI after the transfusion of non‐WBC‐reduced red cells is described. Granulocyte‐agglutinating anti‐5b was detected in his serum, and the crossmatch with the donor granulocytes was positive. The patient also developed a severe exacerbation of hemolysis with renal failure; serologic results excluded an immune hemolytic posttransfusion reaction. The patient recovered from both events after about 1 week. CONCLUSION: Granulocyte‐agglutinating antibodies present in the recipient play an important role in TRALI, and also other factors may contribute to its pathogenesis. The reaction between the PNH patient's antibody (anti‐5b) and transfused WBCs was found not only to be responsible for the respiratory distress but also
Who reads Transfusion-related Acute Lung Injury Due to Granulocyte-agglutinating Antibody in a Patient with Paroxysmal Nocturnal Hemoglobinuria?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- B. Żupańska; M. Uhrynowska; L. Konopka
- Publisher
- Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)