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Folded Emitters for Nanoelectrospray Ionization Mass Spectrometry by Andrea E. Kirby; Mais J. Jebrail; Hao Yang; Aaron R. Wheeler is a Chemistry article available to read on EtoBox.

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## Abstract Electrospray ionization (ESI) has revolutionized mass spectrometry (MS), providing a facile method for the ionization of macromolecules for analysis by mass. The development of nanoESI‐MS has further extended the utility of ESI‐MS, permitting the analysis of small‐volume samples with enhanced sensitivity over conventional ESI‐MS. Traditional nanoESI‐MS experiments use pulled‐glass capillary emitters, which are expensive to purchase and require specialized instruments and training to fabricate in‐house. Furthermore, these emitters suffer from problems including clogging, sample contamination, and irreproducible spray stability. Here, we report a new emitter for nanoESI‐MS, made by folding small pieces of polyimide tape. In comparison with conventional pulled‐glass capillary emitters, the new emitters are inexpensive and simple to make. Their low cost makes them disposable after a single use, such that sample contamination or clogging is never a problem. Emitter performance has been evaluated for diverse analytes encompassing a large mass range, including small molecules, peptides, proteins, and synthetic polymers. In all cases, the performance is similar to that of pulle

Who reads Folded Emitters for Nanoelectrospray Ionization Mass Spectrometry?

Author

Andrea E. Kirby; Mais J. Jebrail; Hao Yang; Aaron R. Wheeler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)