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HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis by Wesley H. Stepp; Zainab Farzal; Adam J. Kimple; Charles S. Ebert; Brent A. Senior; Adam M. Zanation; Brian D. Thorp is a Medicine article available to read on EtoBox.

What is HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis about?

## Objectives: To date, there is still a significant debate on the role of human papilloma virus (hpv) infection in transformation of inverted papillomas (ips) to squamous cell carcinoma (scc). this study was designed to determine if the presence of hpv in a sinonasal ip increases the risk of malignant transformation to ipscc. ## Methods: Following preferred reporting items for systematic reviews and meta-analyses (prisma) guidelines, 19 high-quality case-control and cohort studies with tissue-diagnosed ip or ipscc and hpv diagnosis were analyzed. odds ratios (ors) and 95% confidence intervals (cis) were calculated using the mantel-haenszel method with correction for random effects. subgroup, publication bias and a sensitivity analyses were also performed. ## Results: Nineteen studies with minimal bias met the inclusion criteria for quality and identified hpv infection in an ip. the pooled data revealed a strong association with progression to malignancy with an unweighted, pooled or of 2.38 (ci 1.47 to 3.83) and a weighted or of 2.80 (ci 1.42 to 5.51). sensitivity analysis revealed that no single study contributed significantly to our pooled or calculations (ors 2.52 to 3.57). sub

Who reads HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis?

Author

Wesley H. Stepp; Zainab Farzal; Adam J. Kimple; Charles S. Ebert; Brent A. Senior; Adam M. Zanation; Brian D. Thorp

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)