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Can I read Crosstalk of Low Density Lipoprotein and Liposome as a Paradigm for Targeting of 5-Fluorouracil Into Hepatic Cells: Cytotoxicity and Liver Deposition on EtoBox?
Crosstalk of Low Density Lipoprotein and Liposome as a Paradigm for Targeting of 5-Fluorouracil Into Hepatic Cells: Cytotoxicity and Liver Deposition by Saleh A. Alanazi; Gamaleldin I. Harisa; Mohamed M. Badran; Fars K. Alanazi; Ehab Elzayat; Abdullah H. Alomrani; Osaid T. Al Meanazel; Ahmed T. Al Meanazel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Crosstalk of Low Density Lipoprotein and Liposome as a Paradigm for Targeting of 5-Fluorouracil Into Hepatic Cells: Cytotoxicity and Liver Deposition about?
This study aimed to utilize cholesterol conjugation of 5-fluorouracil (5-FUC) and liposomal formulas to enhance the partitioning of 5-FU into low density lipoprotein (LDL) to target hepatocellular carcinoma (HCC). Thus, 5-FU and 5-FUCwere loaded into liposomes. Later, the direct loading and transfer of 5-FU, and 5-FUC from liposomes into LDL were attained. The preparations were characterized in terms of particle size, zeta potential, morphology, entrapment efficiency, and cytotoxicity using the HepG2 cell line. Moreover, the drug deposition into the LDL and liver tissues was investigated. The present results revealed that liposomal preparations have a nanosize range (155 -194 nm), negative zeta potential (-0.82 to -16 mV), entrapment efficiency of 69% for 5-FU, and 66% for 5-FUC. Moreover, LDL particles have a nanosize range (28-49 nm), negative zeta potential (-17 to -27 mV), and the entrapment efficiency is 11% for 5-FU and 85% for 5-FUC. Furthermore, 5-FUC loaded liposomes displayed a sustained release profile (57%) at 24 h compared to fast release (92%) of 5-FU loaded liposomes. 5-FUC and liposomal formulas enhanced the transfer of 5-FUC into LDL compared to 5-FU. 5-FUC loaded
Who reads Crosstalk of Low Density Lipoprotein and Liposome as a Paradigm for Targeting of 5-Fluorouracil Into Hepatic Cells: Cytotoxicity and Liver Deposition?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Saleh A. Alanazi; Gamaleldin I. Harisa; Mohamed M. Badran; Fars K. Alanazi; Ehab Elzayat; Abdullah H. Alomrani; Osaid T. Al Meanazel; Ahmed T. Al Meanazel
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)