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Efficacy of combined treatment with human adipose tissue stem cell‐derived exosome‐containing solution and microneedling for facial skin aging: A 12‐week prospective, randomized, split‐face study by Gyeong‐Hun Park; Hyuck Hoon Kwon; Joon Seok; Steven Hoseong Yang; Joon Lee; Byung Chul Park; Eun Shin; Kui Young Park is a Medicine article available to read on EtoBox.
What is Efficacy of combined treatment with human adipose tissue stem cell‐derived exosome‐containing solution and microneedling for facial skin aging: A 12‐week prospective, randomized, split‐face study about?
## Abstract ## Background Studies have reported promising results of mesenchymal stem cell therapies for skin aging. However, in the use of mesenchymal stem cells, some drawbacks including rarely possible tumorigenicity and low engraftment rates have limited their widespread clinical use. Adipose tissue stem cell‐derived exosomes (ASCEs) are emerging as effective cell‐free therapeutic agents. ## Aims It was evaluated the clinical efficacy of combining the application of human ASCE‐containing solution (HACS) with microneedling to treat facial skin aging. ## Methods A 12‐week, prospective, randomized, split‐face, comparative study was conducted. Twenty‐eight individuals underwent three treatment sessions separated by 3‐week intervals and were followed up for 6 weeks after the last session. At each treatment session, HACS and microneedling were administered to one side of the face, and normal saline solution and microneedling were administered to the other side as a control. ## Results The Global Aesthetic Improvement Scale score was significantly higher on the HACS‐treated side than on the control side at the final follow‐up visit (p = 0.005). Objective measurements obtained by diffe
Who reads Efficacy of combined treatment with human adipose tissue stem cell‐derived exosome‐containing solution and microneedling for facial skin aging: A 12‐week prospective, randomized, split‐face study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gyeong‐Hun Park; Hyuck Hoon Kwon; Joon Seok; Steven Hoseong Yang; Joon Lee; Byung Chul Park; Eun Shin; Kui Young Park
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)