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DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment Book 7) by Manel Esteller is a nonfiction available to read on EtoBox.

What is DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment Book 7) about?

Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of can

Who reads DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment Book 7)?

Author

Manel Esteller

Publisher

Springer Netherlands : Imprint : Springer

Published

2005

Language

EN

ISBN

9786610284122

Category

nonfiction

Subjects

Medical, Science, Technology