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Induction of Myocardial Heat Shock Protein 70 During Cardiac Surgery by Taggart, David P.; Bakkenist, Christopher J.; Biddolph, Simon C.; Graham, Andrew K.; McGee, James O'D. is a Medicine article available to read on EtoBox.

What is Induction of Myocardial Heat Shock Protein 70 During Cardiac Surgery about?

Animal experiments have shown that members of the heat shock protein (HSP) family have cytoprotective properties against ischaemia. In experimentally induced cardiac ischaemia, the induction of HSP70s correlates with reduced infarct size and enhanced myocardial function and endothelial recovery. Direct evidence that increased myocardial HSP70 expression results in cytoprotection during ischaemia has also been obtained using transgenic mice overexpressing either rat or human HSP72. This study examined the induction and expression of myocardial HSP70s after an obligatory period of ischaemia in patients during cardiac surgery. The level of HSP72/HSC73 protein in Tru-cut biopsies of the myocardium, taken before and after an acute ischaemic insult, was examined using a polyclonal antibody. The amount of HSP72 mRNA in the biopsies was also determined by reverse transcriptase polymerase chain reaction (RT-PCR) and correlated with HSP72/HSC73 protein expression. In four patients subjected to brief alternating periods of normothermic ischaemia and reperfusion, the amount of myocardial HSP72/HSC73 protein was increased several fold after ischaemic insult. This was accompanied by increased ex

Who reads Induction of Myocardial Heat Shock Protein 70 During Cardiac Surgery?

Author

Taggart, David P.; Bakkenist, Christopher J.; Biddolph, Simon C.; Graham, Andrew K.; McGee, James O'D.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1997

Language

EN

Field

Medicine (Health Sciences)