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Preparation of magnetite and tumor dual-targeting hollow polymer microspheres with pH-sensitivity for anticancer drug-carriers by Xiaoying Yang; Lei Chen; Bin Han; Xinlin Yang; Hongquan Duan is a Materials Science article available to read on EtoBox.

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The hollow poly(N,N 0 -methylenebisacrylamide-co-methacrylic acid) (P(MBAAm-co-MAA)) microspheres were prepared by the selective removal of poly(methacrylic acid) (PMAA) core from the corresponding PMAA/P(MBAAm-co-MAA) core-shell microspheres, which were synthesized via a two-stage distillation precipitation polymerization. The magnetic Fe 3 O 4 nanoparticles onto the surface of hollow P(MBAAm-co-MAA) microspheres via partial oxidation of ferrous salt during the chemical deposition in the presence of potassium nitrate as oxidant with the aid of hexamethylene tetramine and the magnetic hollow microspheres were further functionalized with folic acid (FA) via the chemical linkage with amino groups of 3aminopropyl triethoxysilane (APS)-modified P(MBAAm-co-MAA)@Fe 3 O 4 microspheres to afford the magnetite and tumor dual-targeting hollow microspheres. The resultant dual-targeting hollow polymer microspheres with pH-sensitivity were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transform infrared-spectrometer (FT-IR), UVevis absorption spectroscopy, and vibrating sample magnetometer (VSM). Finally, the drug loading capacities of the magn

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Author

Xiaoying Yang; Lei Chen; Bin Han; Xinlin Yang; Hongquan Duan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0032-3861)

Published

2010

Language

EN

Field

Materials Science (Physical Sciences)