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Regulation of processing bodies: From viruses to cancer epigenetic machinery by Sunmathy Kanakamani; Padmanaban S. Suresh; Thejaswini Venkatesh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Regulation of processing bodies: From viruses to cancer epigenetic machinery about?

Processing bodies (PBs) are 100-300 nm cytoplasmic messenger ribonucleoprotein particle (mRNP) granules that regulate eukaryotic gene expression. These cytoplasmic compartments harbor messenger RNAs (mRNAs) and several proteins involved in mRNA decay, microRNA silencing, nonsense-mediated mRNA decay, and splicing. Though membrane-less, PB structures are maintained by RNA-protein and protein-protein interactions. PB proteins have intrinsically disordered regions and low complexity domains, which account for its liquid to liquid phase separation. In addition to being dynamic and actively involved in the exchange of materials with other mRNPs and organelles, they undergo changes on various cellular cues and environmental stresses, including viral infections. Interestingly, several PB proteins are individually implicated in cancer development, and no study has addressed the effects on PB dynamics after epigenetic modifications of cancer-associated PB genes. In the current review, we summarize modulations undergone by P bodies or P body components upon viral infections. Furthermore, we discuss the selective and widely investigated PB proteins that undergo methylation changes in cancer a

Who reads Regulation of processing bodies: From viruses to cancer epigenetic machinery?

Author

Sunmathy Kanakamani; Padmanaban S. Suresh; Thejaswini Venkatesh

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1065-6995)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)