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Epidermal Growth Factor Family and Renal Cell Carcinoma: Expression and Prognostic Impact by Hofmockel, Georg; Riess, Stefan; Bassukas, Ioannis D.; Dämmrich, Jobst is a Medicine article available to read on EtoBox.

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## Objective: Expression and prognostic impact of some exponents of the epidermal growth factor (egf) family in renal cell carcinoma (rcc) were examined. ## Materials and methods: Egf, transforming growth factor-alpha (tgf-alpha), egf receptor (egf-r), and c-erb b-2 were determined immunohistochemically in formalin-fixed paraffin-embedded tumor samples of 30 patients with locally confined rccs. the prognostic significance of these growth factors and their receptors as well as of tumor stage and malignancy grade was examined with respect to survival and tumor recurrence by following up the fate of the patients after nephrectomy (mean follow-up time 5.2 years). ## Results: The members of the egf family and their receptors studied were expressed to a variable degree in all rccs investigated. however, using log-rank tests in kaplan-meier plots only tumor stage (p < 0.0007) and malignancy grade (p 0.05, respectively) exhibited prognostic significance with respect to both survival and disease-free period. on the contrary, there was a significant correlation between egf and tgf-alpha (p < 0.001), egf and egf-r (p = 0.028), egf-r and c-erb b-2 (p = 0.0009), and-inversely related-between

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Author

Hofmockel, Georg; Riess, Stefan; Bassukas, Ioannis D.; Dämmrich, Jobst

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0302-2838)

Published

1997

Language

EN

Field

Medicine (Health Sciences)