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Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-γ, IL-4, IL-5 and IL-10 with age by Francisca Mutapi; Georgina Winborn; Nicholas Midzi; Matthew Taylor; Takafira Mduluza; Rick M Maizels is a Medicine article available to read on EtoBox.

What is Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-γ, IL-4, IL-5 and IL-10 with age about?

## Background The rate of development of parasite-specific immune responses can be studied by following their age profiles in exposed and infected hosts. This study determined the cytokine-age profiles of Zimbabweans resident in a __Schistosoma haematobium__ endemic area and further investigated the relationship between the cytokine responses and infection intensity. ## Methods Schistosome adult worm antigen-specific IFN-γ, IL-4, IL-5 and IL-10 cytokine responses elicited from whole blood cultures were studied in 190 Zimbabweans exposed to __S. haematobium__ infection (aged 6 to 40 years old). The cytokines were measured using capture ELISAs and the data thus obtained together with __S. haematobium__ egg count data from urine assays were analysed using a combination of parametric and nonparametric statistical approaches. ## Results Age profiles of schistosome infection in the study population showed that infection rose to peak in childhood (11–12 years) followed by a sharp decline in infection intensity while prevalence fell more gradually. Mean infection intensity was 37 eggs/10 ml urine (SE 6.19 eggs/10 ml urine) while infection prevalence was 54.7%. Measurements of parasite-spec

Who reads Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-γ, IL-4, IL-5 and IL-10 with age?

Author

Francisca Mutapi; Georgina Winborn; Nicholas Midzi; Matthew Taylor; Takafira Mduluza; Rick M Maizels

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2007

Language

EN

Field

Medicine (Health Sciences)