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Peripheral Nerve Hyperexcitability Syndromes by Komal Sawlani; Bashar Katirji is a Medicine article available to read on EtoBox.

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## Purpose of review: This article provides a review of the clinical phenotypes and evaluation of peripheral nerve hyperexcitability syndromes. these rare diagnoses include cramp-fasciculation syndrome, isaacs syndrome, and morvan syndrome. recent investigations have led to an understanding of the autoimmune underpinnings of these conditions and their specific associated antibodies. as the presentation of peripheral nerve hyperexcitability syndromes includes muscle stiffness, twitches, and spasms, which are also shared with certain central nervous system and myopathic conditions, the differential diagnosis of peripheral nerve hyperexcitability syndromes is reviewed. ## Recent findings: Peripheral nerve hyperexcitability syndromes share clinical and electrodiagnostic evidence of motor nerve instability; however, their clinical presentations are varied. case reviews have helped us understand the spectrum of symptoms associated with the three peripheral nerve hyperexcitability syndromes reviewed here: cramp-fasciculation syndrome, isaacs syndrome, and morvan syndrome. more recently, research has focused on understanding the voltage-gated potassium channel complex antibodies as well as

Who reads Peripheral Nerve Hyperexcitability Syndromes?

Author

Komal Sawlani; Bashar Katirji

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2017

Language

EN

Field

Medicine (Health Sciences)