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Superficially Porous Silica Microspheres for Fast High-performance Liquid Chromatography of Macromolecules by J.J. Kirkland; F.A. Truszkowski; C.H. Dilks Jr.; G.S. Engel is a Chemistry article available to read on EtoBox.

What is Superficially Porous Silica Microspheres for Fast High-performance Liquid Chromatography of Macromolecules about?

Very fast reversed-phase separations of biomacromolecules are performed using columns made with superficially porous silica microsphere column packings ("Poroshell"). These column packings consist of ultra-pure "biofriendly' silica microspheres composed of solid cores and thin outer shells with uniform pores. The excellent kinetic properties of these new column packings allow stable, high-resolution gradient chromatography of polypeptides, proteins, nucleic acids, DNA fragments, etc. in a fraction of the time required for conventional separations. Contrasted with <2-microm non-porous particles, Poroshell packings can be used optimally with existing equipment and greater sample loading capacities, while retaining kinetic (and separation speed) advantages over conventional totally porous particles.

Who reads Superficially Porous Silica Microspheres for Fast High-performance Liquid Chromatography of Macromolecules?

Author

J.J. Kirkland; F.A. Truszkowski; C.H. Dilks Jr.; G.S. Engel

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2000

Language

EN

Field

Chemistry (Physical Sciences)