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Synthesis of Chroman Analogues of Lipoic Acid and Evaluation of Their Activity Against Reperfusion Arrhythmias by Maria Koufaki; Anastasia Detsi; Elissavet Theodorou; Christina Kiziridi; Theodora Calogeropoulou; Athanasios Vassilopoulos; Angeliki P. Kourounakis; Eleni Rekka; Panos N. Kourounakis; Catherine Gaitanaki; Panagiota Papazafiri is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis of Chroman Analogues of Lipoic Acid and Evaluation of Their Activity Against Reperfusion Arrhythmias about?
Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 microM concentration, reduced reperfusion arrhythmias and MDA content on isolated rat heart preparations, with the 2- and 5-subtituted chromans possessing the better cardioprotective activity.
Who reads Synthesis of Chroman Analogues of Lipoic Acid and Evaluation of Their Activity Against Reperfusion Arrhythmias?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Maria Koufaki; Anastasia Detsi; Elissavet Theodorou; Christina Kiziridi; Theodora Calogeropoulou; Athanasios Vassilopoulos; Angeliki P. Kourounakis; Eleni Rekka; Panos N. Kourounakis; Catherine Gaitanaki; Panagiota Papazafiri
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)