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Single-Cell Profiling of Acral Melanoma Infiltrating Lymphocytes Reveals A Suppressive Tumor Microenvironment by aleromagnolo is a document available to read on EtoBox.
What is Single-Cell Profiling of Acral Melanoma Infiltrating Lymphocytes Reveals A Suppressive Tumor Microenvironment about?
The study investigates the immune microenvironment of acral lentiginous melanoma (ALM) using single-cell profiling of tumor-infiltrating lymphocytes (TILs). Findings reveal a suppressive immune environment characterized by lower frequencies of tumor-reactive CD8 T cells and an enrichment of regulatory T cells, which may contribute to the limited efficacy of current immunotherapies for ALM. This research lays the groundwork for developing improved therapeutic strategies targeting the unique immune landscape
- Author
- aleromagnolo
- Language
- EN