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5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope by Peter Milos; Neda Haj-Hosseini; Jan Hillman; Karin Wårdell is a Medicine article available to read on EtoBox.

What is 5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope about?

## Purpose: Fluorescence-guided surgery applying 5-aminolevulinic acid (5-ala) in high-grade gliomas is an established method in adults. in children, results have so far been ambiguous. the aim of this study was to investigate 5-ala-induced fluorescence in pediatric brain tumors by using the surgical microscope and a spectroscopic hand-held probe. ## Methods: Fourteen randomly selected children (age 4-17) with newly mri-verified brain tumors were included. no selection was based on the suspected diagnosis prior to surgery. all patients received 5-ala (20 mg /kg) either orally or via a gastric tube prior to surgery. intratumoral fluorescence was detected with the microscope and the probe. moreover, fluorescence in the skin of the forearm was measured. histopathology samples revealed seven low-grade gliomas, four medulloblastomas, one diffuse intrinsic pontine glioma, one glioblastoma and one atypical meningioma. blood samples were analyzed, and potential clinical side effects were monitored. ## Results: Microscopically, vague fluorescence was visible in two patients. intratumoral fluorescence could be detected in five patients with the probe, including the two patients with vague mi

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Author

Peter Milos; Neda Haj-Hosseini; Jan Hillman; Karin Wårdell

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)