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The role of cytokines and vitamin D in vitiligo pathogenesis by Amir Mohammad Beyzaee; Mohamad Goldust; Anant Patil; Ghasem Rahmatpour Rokni; Samira Beyzaee is a Medicine article available to read on EtoBox.
What is The role of cytokines and vitamin D in vitiligo pathogenesis about?
## Abstract Vitiligo is a pigment‐related disease with a global prevalence of 0.2% to 1.8% associated with considerable burden on quality of life. The treatment is still a challenge because of relapses and/or incomplete re‐pigmentation. Although the exact cause is still unclear, its pathogenesis seems to be justifiable with the autoimmune theory, supported by the results of clinical research. In this narrative review, we aimed to summarize the evidence related to cytokines and vitiligo development. This review is consisted of English articles published in PubMed and Google Scholar concerning levels of inflammatory mediators, especially interleukins, in vitiligo patients over the last 20 years. References of relevant articles were also considered for review. Crucial role of dysregulated levels of interleukins and their synergistic function to each other, in the onset or progression of the disease is evident. The theory of autoimmune vitiligo is reinforced by the results of the studies in the literature, due to the association of pathogenesis with increased secretion of pro‐inflammatory mediators and reduction of anti‐inflammatory mediators. Decreased vitamin D levels may have a cons
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- Author
- Amir Mohammad Beyzaee; Mohamad Goldust; Anant Patil; Ghasem Rahmatpour Rokni; Samira Beyzaee
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)