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Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network by Jin Wang; Martin Haubrock; Kun-Ming Cao; Xu Hua; Chen-Yu Zhang; Edgar Wingender; Jie Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network about?

## Background MicroRNA (miRNA) is a class of small RNAs of ~22nt which play essential roles in many crucial biological processes and numerous human diseases at post-transcriptional level of gene expression. It has been revealed that miRNA genes tend to be clustered, and the miRNAs organized into one cluster are usually transcribed coordinately. This implies a coordinated regulation mode exerted by clustered miRNAs. However, how the clustered miRNAs coordinate their regulations on large scale gene expression is still unclear. ## Results We constructed the miRNA-transcription factor regulatory network that contains the interactions between transcription factors (TFs), miRNAs and non-TF protein-coding genes, and made a genome-wide study on the regulatory coordination of clustered miRNAs. We found that there are two types of miRNA clusters, i.e. homo-clusters that contain miRNAs of the same family and hetero-clusters that contain miRNAs of various families. In general, the homo-clustered as well as the hetero-clustered miRNAs both exhibit coordinated regulation since the miRNAs belonging to one cluster tend to be involved in the same network module, which performs a relatively isolated

Who reads Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network?

Author

Jin Wang; Martin Haubrock; Kun-Ming Cao; Xu Hua; Chen-Yu Zhang; Edgar Wingender; Jie Li

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)