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A Comprehensive Review of Thyroid Hormone Metabolism in the Gut and Its Clinical Implications by Aline C. Fenneman; Eveline Bruinstroop; Max Nieuwdorp; Anne H. van der Spek; Anita Boelen is a Medicine article available to read on EtoBox.

What is A Comprehensive Review of Thyroid Hormone Metabolism in the Gut and Its Clinical Implications about?

Background: The gut is a target organ of thyroid hormone (TH) that exerts its action via the nuclear thyroid hormone receptor a1 (TRa1) expressed in intestinal epithelial cells. THs are partially metabolized via hepatic sulfation and glucuronidation, resulting in the production of conjugated iodothyronines. Gut microbiota play an important role in peripheral TH metabolism as they produce and secrete enzymes with deconjugation activity (b-glucuronidase and sulfatase), via which TH can re-enter the enterohepatic circulation. Summary: Intestinal epithelium homeostasis (the finely tuned balance between cell proliferation and differentiation) is controlled by the crosstalk between triiodothyronine and TRa1 and the presence of specific TH transporters and TH-activating and -inactivating enzymes. Patients and experimental murine models with a dominant-negative mutation in the TRa exhibit gross abnormalities in the morphology of the intestinal epithelium and suffer from severe symptoms of a dysfunctional gastrointestinal tract. Over the past decade, gut microbiota has been identified as an essential factor in health and disease, depending on its compositional and functional profile. This h

Who reads A Comprehensive Review of Thyroid Hormone Metabolism in the Gut and Its Clinical Implications?

Author

Aline C. Fenneman; Eveline Bruinstroop; Max Nieuwdorp; Anne H. van der Spek; Anita Boelen

Publisher

Mary Ann Liebert Inc

Published

2023

Language

EN

Field

Medicine (Health Sciences)