Can I read Physicochemical Features and Peculiarities of Interaction of Antimicrobial Peptides with the Membrane on EtoBox?

Physicochemical Features and Peculiarities of Interaction of Antimicrobial Peptides with the Membrane by Pirtskhalava, Malak; Vishnepolsky, Boris; Grigolava, Maya is a scholarly article available to read on EtoBox.

What is Physicochemical Features and Peculiarities of Interaction of Antimicrobial Peptides with the Membrane about?

Antimicrobial peptides (AMPs) are anti-infectives that have potential as a novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides imply interaction with cell envelope. Comprehensive understanding of peculiarities of interactions of antimicrobial peptides with cell envelope is necessary to perform the task-oriented design of new biotherapeutics, against which for microbes it is hard to work out resistance. In order to enable a de novo design with low costs and in high throughput, in silico predictive models have to be required. To develop the performant predictive model, comprehensive knowledge on mechanisms of action of AMPs has to be possessed. The last knowledge will allow us to encode amino acid sequences expressively and to get success to the choosing of the accurate classifier of AMPs. A shared protective layer of microbial cells is inner, plasmatic membrane. The interaction of AMP with a biological membrane (native and/or artificial) is the most comprehensively studied. We provide a review of mechanisms and results of interaction of AMP with the cell membrane, relying on the survey of physicochemical, aggregative and structural features of AMPs

Author

Pirtskhalava, Malak; Vishnepolsky, Boris; Grigolava, Maya

Published

2020

Language

EN