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Role of Autophagy and Reactive Oxygen Species in Cancer Treatment: Principles and Current Strategies by Neeraj Mishra, Ravinder Kumar Kaundal is a book available to read on EtoBox.

What is Role of Autophagy and Reactive Oxygen Species in Cancer Treatment: Principles and Current Strategies about?

Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.

Author

Neeraj Mishra, Ravinder Kumar Kaundal

Publisher

Springer Nature Switzerland AG

Published

2024

Language

EN

ISBN

9783031664205

Subjects

Science, Biology, Stem