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Assembly of Lipid-containing Viruses by Richard W. Compans; Herbert Meier-Ewert; Peter Palese is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Assembly of Lipid-containing Viruses about?

## Abstract Enveloped viruses which form by budding at the cell surface possess a membrane consisting of a lipid bilayer and a small number of virus‐coded polypeptides. Since viral polypeptides become integral components of the plasma membrane during assembly, the process of synthesis and incorporation into membranes of these proteins may reflect the pathway of plasma membrane assembly. Electron microscopic studies have suggested that viral envelope proteins are incorporated into discrete, localized regions of the plasma membrane which serve as recognition sites for the viral nucleocapsid. In influenza virus‐infected cells, viral polypeptides are associated with cytoplasmic membranes as well as the plasma membrane. The major envelope glycoprotein appears to be synthesized in rough endoplasmic reticulum, and to migrate to smooth membranes after synthesis. Glycosylation is initiated in rough membranes and progresses further in smooth membranes. Unlike the glycoproteins, the major nonglycosylated polypeptide appears to be inserted directly into the plasma membrane. In the presence of 2‐deoxyglucose or high concentrations of glucosamine, aberrant viral glycoproteins are detected which

Who reads Assembly of Lipid-containing Viruses?

Author

Richard W. Compans; Herbert Meier-Ewert; Peter Palese

Publisher

Wiley (John Wiley & Sons); Alan R. Liss, Inc.; Wiley (ISSN 0091-7419)

Published

1974

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)