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Local incidence of Jarisch–Herxheimer reaction in pregnancy following penicillin treatment for syphilis: A case series by Amreet Dhaliwal; Alison A Lopez; Jared Bullard; Vanessa Poliquin is a Medicine article available to read on EtoBox.

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Background: The literature suggests that the Jarisch–Herxheimer (J-H) reaction following antimicrobial treatment of syphilis is common and may precipitate uterine activity. Local practice is to transfer syphilitic parturients beyond gestational age of viability from rural locations to a tertiary care centre for treatment. Study objectives were to delineate local incidence and risk factors for the J-H reaction among pregnant women receiving treatment for syphilis. Methods: A retrospective chart review was conducted on pregnant women diagnosed with syphilis and treated during pregnancy at a tertiary care centre between 2012 and 2018. J-H reaction was defined as having ≥1 of the following symptoms within 24 hours of antibiotic treatment: fever (temperature ≥38°C), clinical description of a painful or itchy skin lesion, headache, hypotension (systolic blood pressure <90 mmHg), uterine contractions, or fetal heart rate decelerations. Descriptive statistical analysis was performed with mean and median used as measures of central tendency for continuous and categorical data, respectively. Results: Fifty-eight charts were eligible for inclusion. Mean maternal age was 25.1 (SD 5.6) years, a

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Author

Amreet Dhaliwal; Alison A Lopez; Jared Bullard; Vanessa Poliquin

Publisher

University of Toronto Press Inc. (UTPress)

Published

2021

Language

EN

Field

Medicine (Health Sciences)