Can I read Molecular Signatures Define Subtypes of Auditory Afferents with Distinct Peripheral Projection Patterns and Physiological Properties on EtoBox?

Molecular Signatures Define Subtypes of Auditory Afferents with Distinct Peripheral Projection Patterns and Physiological Properties by Caroline Siebald; Philippe F. Y. Vincent; Riley T. Bottom; Shuohao Sun; Daniel O. J. Reijntjes; Marco Manca; Elisabeth Glowatzki; Ulrich Müller is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular Signatures Define Subtypes of Auditory Afferents with Distinct Peripheral Projection Patterns and Physiological Properties about?

## Significance Afferent neurons within single sense organs have diverse properties that are crucial for information coding. Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound information to the brain. Several type I SGN subtypes have been distinguished by anatomical, electrophysiological, and molecular properties, but whether these properties are linked is unclear. By creating reporter lines for molecular type I SGN subtypes and characterizing their properties, we show that molecularly and physiologically defined SGN subtypes correlate only in part. Molecular subtypes consolidate their gene expression program and innervation specificity postnatally. The molecular subtype-specific lines characterized here are important tools for investigating the roles of physiologically distinct type I SGNs in sound coding.

Who reads Molecular Signatures Define Subtypes of Auditory Afferents with Distinct Peripheral Projection Patterns and Physiological Properties?

Author

Caroline Siebald; Philippe F. Y. Vincent; Riley T. Bottom; Shuohao Sun; Daniel O. J. Reijntjes; Marco Manca; Elisabeth Glowatzki; Ulrich Müller

Publisher

National Academy of Sciences

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)