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Hospital distribution, seasonality, time trends and antifungal susceptibility profiles of all Aspergillus species isolated from clinical samples from 2015 to 2022 in a tertiary care hospital by Iacopo Franconi; Cosmeri Rizzato; Emilia Ghelardi; Antonella Lupetti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background __Aspergillus__ species cause a variety of serious clinical conditions with increasing trend in antifungal resistance. The present study aimed at evaluating hospital epidemiology and antifungal susceptibility of all isolates recorded in our clinical database since its implementation. ## Methods Data on date of isolation, biological samples, patients’ age and sex, clinical settings, and antifungal susceptibility tests for all __Aspergillus__ spp. isolated from 2015 to 2022 were extracted from the clinical database. Score test for trend of odds, non-parametric Mann Kendall trend test and logistic regression analysis were used to analyze prevalence, incidence, and seasonality of __Aspergillus__ spp. isolates. ## Results A total of 1126 __Aspergillus__ spp. isolates were evaluated. __A. fumigatus__ was the most prevalent (44.1%) followed by __A. niger__ (22.3%), __A. flavus__ (17.7%) and __A. terreus__ (10.6%). __A. niger__ prevalence increased over time in intensive care units (__p__-trend = 0.0051). Overall, 16 (1.5%) were not susceptible to one azole compound, and 108 (10.9%) to amphotericin B, with __A. niger__ showing the highest percentage (21.9%). The risk of detec

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Author

Iacopo Franconi; Cosmeri Rizzato; Emilia Ghelardi; Antonella Lupetti

Publisher

BioMed Central

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)