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Soy Isoflavones Avert Chronic Inflammation-induced Bone Loss and Vascular Disease by Elizabeth A Droke; Kelly A Hager; Megan R Lerner; Stan A Lightfoot; Barbara J Stoecker; Daniel J Brackett; Brenda J Smith is a Medicine article available to read on EtoBox.

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## Background Evidence from epidemiological, clinical and animal studies suggests a link may exist between low bone density and cardiovascular disease, with inflammatory mediators implicated in the pathophysiology of both conditions. This project examined whether supplementation with soy isoflavones (IF), shown to have anti-inflammatory properties, could prevent tissue expression of TNF-α and the development of skeletal pathology in an animal model of chronic inflammation. ## Methods Eight-week old, intact, female C57BL/6J mice were used. In Phase 1, a lipopolysaccharide (LPS)-dose response study (0, 0.133, 1.33 and 13.3 μg/d) was conducted to determine the LPS dose to use in Phase 2. The results indicated the 1.33 μg LPS/d dose produced the greatest decrease in lymphocytes and increase in neutrophils. Subsequently, in Phase 2, mice were randomly assigned to one of six groups (n = 12–13 per group): 0 or 1.33 μg LPS/d (placebo or LPS) in combination with 0, 126 or 504 mg aglycone equivalents of soy IF/kg diet (Control, Low or High dose IF). Mice were fed IF beginning 2 wks prior to the 30-d LPS study period. ## Results At the end of the study, no differences were detected in final b

Who reads Soy Isoflavones Avert Chronic Inflammation-induced Bone Loss and Vascular Disease?

Author

Elizabeth A Droke; Kelly A Hager; Megan R Lerner; Stan A Lightfoot; Barbara J Stoecker; Daniel J Brackett; Brenda J Smith

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1476-9255)

Published

2007

Language

EN

Field

Medicine (Life Sciences)