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Can I read Targeting the Hallmarks of Cancer: the Effects of Silibinin on Proliferation, Cell Death, Angiogenesis, and Migration in Colorectal Cancer on EtoBox?
Targeting the Hallmarks of Cancer: the Effects of Silibinin on Proliferation, Cell Death, Angiogenesis, and Migration in Colorectal Cancer by Sameri, Saba (author);Mohammadi, Chiman (author);Mehrabani, Mehrnaz (author);Najafi, Rezvan (author) is a Medicine article available to read on EtoBox.
What is Targeting the Hallmarks of Cancer: the Effects of Silibinin on Proliferation, Cell Death, Angiogenesis, and Migration in Colorectal Cancer about?
## Background Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against different types of cancers. In the present study, we investigated the anti-cancer activities of silibinin on CT26 mouse colon cell line. ## Methods CT26 cells were treated with different concentrations of silibinin. To examine the cytotoxic effect of silibinin on proliferation, apoptosis, autophagy, angiogenesis, and migration, MTT, colony-forming assay, Annexin V/PI flow cytometry, RT-qPCR, and Scratch assay were used. ## Results Silibinin was found to significantly reduce CT26 cells survival. Furthermore, silibinin strongly induced apoptosis and autophagy by up-regulating the expression of __Bax__, __Caspase-3__, __Atg5__, __Atg7__ and __BECN1__ and down-regulating __Bcl-2__. Silibinin considerably down-regulated the expression of __COX-2__, __HIF-1α__, __VEGF__, __Ang-2__, and __Ang-4__ as well as the expression of __MMP-2__, __MMP-9__, __CCR-2__ and __CXCR-4__. ## Conclusions The present study revealed that silibinin shows anticancer activities by targeting proliferation, cell survival, angiogenesis, and migration of CT26 cells.
Who reads Targeting the Hallmarks of Cancer: the Effects of Silibinin on Proliferation, Cell Death, Angiogenesis, and Migration in Colorectal Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sameri, Saba (author);Mohammadi, Chiman (author);Mehrabani, Mehrnaz (author);Najafi, Rezvan (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)