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1. This study examined the effects of subchronic exposure to a combination decoction of Centella asiatica, Imperata cylindrica, and Orthosiphon stamineus (CIO) at therapeutic, MATC, and LC50 doses on hepatocyte necrosis in adult zebrafish. 2. Zebrafish were divided into 4 groups - a control group and groups given the CIO decoction at 216 mg/L (therapeutic dose), 249 mg/L (MATC dose), and 357 mg/L (LC50 dose) for 14 days. Histopathological examination found increased hepatocyte necrosis at the MATC and LC5

Author

Dhigna Luthfiyani

Language

EN