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Abnormal levels of maternal serum human chorionic gonadotropin and alpha‐fetoprotein in the second trimester: Relation to fetal weight and preterm delivery by L. P. Morssink; L. H. Kornman; J. R. Beekhuis; B. T. H. M. de Wolf; A. Mantingh is a Medicine article available to read on EtoBox.

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## Abstract The aim of this prospective descriptive cross‐sectional study was to examine the clinical significance of abnormal maternal serum human chorionic gonadotropin (MShCG) and alpha‐fetoprotein (MSAFP) in the second trimester of pregnancy. The study group comprised 8892 women with a singleton pregnancy, who were screened for a neural tube defect and Down's syndrome. Exclusion criteria were unknown pregnancy outcome, a congenital anomaly, delivery before 25 weeks of amenorrhoea, or known insulin‐dependent diabetes. MSAFP and MShCG were determined between 15 and 20 weeks' amenorrhoea. An abnormal result was defined as (a) MSAFP or MShCG ≥ 2·5 MOM, (b) MSAFP or MShCG ≥ 0·5 MOM, and (c) MSAFP and MShCG ≥ 2·5 MOM. Birth weight percentiles and the duration of amenorrhoea at the time of delivery were employed as outcome parameters. Of the women with an abnormally elevated MSAFP, 9·4 per cent had an extremely small‐for‐gestational age (SGA) infant (<2·3rd percentile; __P__<0·01, relative risk 4·5), 27·1 per cent had an SGA infant (P<0·01, relative risk 2·7), and 14·3 per cent had an appropriate‐for‐gestational age (AGA) infant that was delivered preterm (<259 days; __P__<0·01, relat

Who reads Abnormal levels of maternal serum human chorionic gonadotropin and alpha‐fetoprotein in the second trimester: Relation to fetal weight and preterm delivery?

Author

L. P. Morssink; L. H. Kornman; J. R. Beekhuis; B. T. H. M. de Wolf; A. Mantingh

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

1995

Language

EN

Field

Medicine (Health Sciences)