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Differential cardiovascular and renal benefits of SGLT2 inhibitors and GLP1 receptor agonists in patients with type 2 diabetes mellitus by Chee Hae Kim; In-Chang Hwang; Hong-Mi Choi; Chang Ho Ahn; Yeonyee E. Yoon; Goo-Yeong Cho is a Medicine article available to read on EtoBox.
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## Background: The differential benefits of sodium-glucose cotransporter 2 inhibitors (sglt2i) and glucagon-like peptide-1 receptor agonists (glp1ra) in cardiovascular or renal outcomes have not been fully investigated. ## Methods: Patients with diabetes prescribed sglt2i or glp1ra were retrospectively identified. patients treated with antihyperglycemic medications other than sglt2i or glp1ra were used as a control group. primary outcomes were composite ischemic events (acute coronary syndrome, coronary revascularization, and stroke) and a composite of heart failure and renal events (hospitalization for heart failure, renal death, initiation of renal replacement therapy, and renal admission). ## Results: During a median 38.7 months of follow-up, the incidence of composite ischemic events tended to be lower in the glp1ra group (annualized rate 0.82% per person-year) than in the other groups (1.68% per person-year in the sglt2i group and 1.36% per person-year in the control group). the risk of a composite of heart failure and renal outcomes was significantly lower in the sglt2i group than in the glp1ra and control groups (0.86% per person-year, 2.33% per person-year, and 1.48% per pe
Who reads Differential cardiovascular and renal benefits of SGLT2 inhibitors and GLP1 receptor agonists in patients with type 2 diabetes mellitus?
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- Author
- Chee Hae Kim; In-Chang Hwang; Hong-Mi Choi; Chang Ho Ahn; Yeonyee E. Yoon; Goo-Yeong Cho
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)