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Can I read Synergistic Effects of Fluid Shear Stress and Cyclic Circumferential Stretch on Vascular Endothelial Cell Morphology and Cytoskeleton on EtoBox?
Synergistic Effects of Fluid Shear Stress and Cyclic Circumferential Stretch on Vascular Endothelial Cell Morphology and Cytoskeleton by Zhao, Shumin; Suciu, Andreas; Ziegler, Thierry; Moore, James E.; BuÌrki, Ernst; Meister, Jean-Jacques; Brunner, Hans R. is a Medicine article available to read on EtoBox.
What is Synergistic Effects of Fluid Shear Stress and Cyclic Circumferential Stretch on Vascular Endothelial Cell Morphology and Cytoskeleton about?
__Abstract__ The development of atherosclerosis is thought to be initiated by a dysfunctional state of the vascular endothelium. The proposal that mechanical forces play a role in the localization of this disease has led researchers to develop in vitro models to assess their effects on cultured endothelial cells. The arterial endothelium is exposed simultaneously to circumferential hoop stretch and wall shear stress, yet previous investigations have focused on the isolated effects of either cyclic stretch or shear stress. The influence of physiological levels of combined shear stress and hoop stretch on the morphology and F-actin organization of bovine aortic endothelial cells was investigated. Cells subjected for 24 hours to shear stresses higher than 2 dyne/cm ^2^ or to hoop stretch greater than 2% elongated significantly compared with unstressed controls and oriented along the direction of flow and perpendicular to the direction of stretch. Exposure to more than 4% stretch significantly enhanced the responses to shear stress. Both shear stress and hoop stretch induced formation of stress fibers that were aligned with the cells’ long axes. Simultaneous exposure to both stimuli ap
Who reads Synergistic Effects of Fluid Shear Stress and Cyclic Circumferential Stretch on Vascular Endothelial Cell Morphology and Cytoskeleton?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zhao, Shumin; Suciu, Andreas; Ziegler, Thierry; Moore, James E.; BuÌrki, Ernst; Meister, Jean-Jacques; Brunner, Hans R.
- Publisher
- Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)