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Improved Hemocompatibility of Poly(ethylene Terephthalate) Modified with Various Thiol-containing Groups by Heather Gappa-Fahlenkamp; Randy S. Lewis is a Engineering article available to read on EtoBox.

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Thiol groups were attached to polyethylene terephthalate (PET) to promote the transfer of a known platelet inhibitor, nitric oxide (NO), from nitrosated thiols naturally found in the body to PET, followed by the release of NO from PET to prevent platelet adhesion. In order to immobilize the most thiols on the modified polymer, the processing parameters used to attach the following three thiol containing groups were assessed: L-cysteine, 2-iminothiolane, and a cysteine polypeptide. When comparing the immobilized concentrations of thiol groups from each of the optimized processes the amount of immobilized thiol groups increased in order with the following groups: cysteine polypeptide <2-iminothiolane

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Author

Heather Gappa-Fahlenkamp; Randy S. Lewis

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2005

Language

EN

Field

Engineering (Physical Sciences)