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Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts by Betjes, Michiel G. H.; Sablik, Kasia S.; Otten, Henny G.; Roelen, Dave L.; Claas, Frans H.; de Weerd, Annelies is a Medicine article available to read on EtoBox.

What is Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts about?

## Background The presence of donor-specific antibodies (DSAs) against HLA before kidney transplantation has been variably associated with decreased long-term graft survival. Data on the relation of pretransplant DSA with rejection and cause of graft failure in recipients of donor kidneys are scarce. ## Methods Patients transplanted between 1995 and 2005 were included and followed until 2016. Donor-specific antibodies before transplantation were determined retrospectively. For cause, renal transplant biopsies were reviewed. ## Results Pretransplant DSAs were found in 160 cases on a total of 734 transplantations (21.8%). In 80.5% of graft failures, a diagnostic renal biopsy was performed. The presence of pretransplant DSA (DSApos) increased the risk of graft failure within the first 3 months after transplantation (5.2% vs. 9.4%) because of rejection with intragraft thrombosis (__p__ < 0.01). One year after transplantation, DSApos recipients had an increased hazard for antibody-mediated rejection at 10 years (9% DSAneg vs. 15% DSApos, __p__ < 0.01). One year after transplantation, DSApos recipients had an increased hazard for antibody-mediated rejection at 10 years (9% DSAneg vs. 15%

Who reads Pretransplant Donor-Specific Anti-HLA Antibodies and the Risk for Rejection-Related Graft Failure of Kidney Allografts?

Author

Betjes, Michiel G. H.; Sablik, Kasia S.; Otten, Henny G.; Roelen, Dave L.; Claas, Frans H.; de Weerd, Annelies

Publisher

Hindawi Limited; London: Hindawi, [2009]- (ISSN 2090-0007)

Published

2020

Language

EN

Field

Medicine (Health Sciences)