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Determination of melanotan‐II in rat plasma by liquid chromatography/tandem mass spectrometry: determination of pharmacokinetic parameters in rat following intravenous administration by S. Mock; X. Shen; C. Tamvakopoulos is a Chemistry article available to read on EtoBox.
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## Abstract A method is described for the determination of melanotan‐II (MT‐II), a synthetic cyclic heptapeptide analog of α‐melanocyte‐stimulating hormone (α‐MSH), in rat plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The analyte is recovered from plasma by solid‐phase extraction (SPE) and subsequently analyzed by LC/MS/MS. A SPE procedure using OASIS 96‐well plates is used for extraction of MT‐II from rat plasma. Using the described approach a limit of quantitation of 5 ng/mL was achieved in rat plasma. This level of sensitivity allowed the determination of pharmacokinetic parameters, following intravenous administration of MT‐II in rat. Copyright © 2002 John Wiley & Sons, Ltd.
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- Author
- S. Mock; X. Shen; C. Tamvakopoulos
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)
- Published
- 2002
- Language
- EN
- Field
- Chemistry (Physical Sciences)