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Is endothelial function impaired among women with placenta-mediated fetal growth restriction? Evidence from a prospective cohort study using peripheral artery tonometry by Michal Kirshenbaum; Lior Topaz; Micha Baum; Shali Mazaki-Tovi; Yoav Yinon is a Medicine article available to read on EtoBox.

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## Introduction: Women with pregnancies complicated by iugr are at increased risk for future cardiovascular disease. nevertheless, it is unknown whether endothelial function of women with pregnancies complicated by iugr is already impaired during pregnancy. hence, we evaluated maternal endothelial function in pregnancies complicated by iugr due to placental dysfunction. ## Methods: Prospective cohort study assessing systemic endothelial function of women with singleton pregnancies and estimated fetal weight (efw) below 10th percentile and abnormal umbilical artery flow (n = 15). control group included women with singleton pregnancies and normal efw (n = 22). endothelial function was assessed using endopatTM device which evaluates the change in peripheral vascular tone in reaction to temporal ischemia, a process called reactive hyperemia. the ratio of the readings before and after ischemia is used to assess endothelial function and called reactive hyperemia index (rhi). low rhi values indicate endothelial dysfunction. ## Results: The median gestational age at endopat examination was comparable between the iugr and control groups (32; iqr 31,33; p = 0.18). the median rhi was signific

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Author

Michal Kirshenbaum; Lior Topaz; Micha Baum; Shali Mazaki-Tovi; Yoav Yinon

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)