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Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa by Stefania Glieca; Eride Quarta; Benedetta Bottari; Elena Bancalari; Saverio Monica; Erika Scaltriti; Martina Tambassi; Lisa Flammini; Simona Bertoni; Annalisa Bianchera; Valentina Fainardi; Susanna Esposito; Giovanna Pisi; Ruggero Bettini; Fabio Sonvico; Francesca Buttini is a Medicine article available to read on EtoBox.
What is Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa about?
Objectives: The aim of the project was to develop and characterise powders containing a probiotic ( Lactiplantibacillus plantarum [ Lpb. plantarum ] , Lacticaseibacillus rhamnosus, or Lactobacillus acidophilus ) to be administered to the lung for the containment of pathogen growth in patients with lung infections. Methods: The optimised spray drying process for the powder manufacturing was able to preserve viability of the bacteria, which decreased of only one log unit and was maintained up to 30 days. Results: Probiotic powders showed a high respirability (42%-50% of particles had a size < 5 μm) suitable for lung deposition and were proven safe on A549 and Calu-3 cells up to a concentration of 10 7 colonyforming units/mL. The Lpb. plantarum adhesion to both cell lines tested was at least 10%. Surprisingly, Lpb. plantarum powder was bactericidal at a concentration of 10 6 colony-forming units/mL on P. aeruginosa , whereas the other two strains were bacteriostatic. Conclusion: This work represents a promising starting point to consider a probiotic inhalation powder a value in keeping the growth of pathogenic microflora in check during the antibiotic inhalation therapy suspension in
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- Author
- Stefania Glieca; Eride Quarta; Benedetta Bottari; Elena Bancalari; Saverio Monica; Erika Scaltriti; Martina Tambassi; Lisa Flammini; Simona Bertoni; Annalisa Bianchera; Valentina Fainardi; Susanna Esposito; Giovanna Pisi; Ruggero Bettini; Fabio Sonvico; Francesca Buttini
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)