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A Novel Cyanobacterial Nostocyclopeptide is a Potent Antitoxin against Microcystins by Jouni Jokela ; Lars Herfindal ; Matti Wahlsten; Perttu Permi; Frode Selheim ; Vitor Vasconçelos; Stein Ove Døskeland; Kaarina Sivonen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract __Cyanobacterial hepatotoxins (microcystins and nodularins) cause numerous animal poisonings worldwide each year and are threats to human health. However, we found that extracts from several cyanobacteria isolates failed to induce hepatotoxicity even if they contained high concentrations of the liver toxin microcystin. The antitoxic activity abolishes all morphological hallmarks of microcystin‐induced apoptosis, and therefore invalidates cell‐based assays of the microcystin content of bloom‐forming cyanobacteria. The antitoxin was purified from a cyanobacterial isolate (__Nostoc __sp. XSPORK 13A) from the Baltic Sea, and the activity was shown to reside in a novel cyclic peptide of the nostocyclopeptide family (nostocyclopeptide M1, Ncp‐M1) that consists of seven amino acids (Tyr^1^‐Tyr^2^‐D‐HSe^3^‐L‐Pro^4^‐L‐Val^5^‐(2__S__,4__S__)‐4‐MPr^6^‐Tyr^7^;__ M__~W~=881) with an imino linkage between Tyr1 and Tyr7. Ncp‐M1 did not compete with labelled microcystin for binding to protein phosphatase 2A; this explains why the antitoxin did not interfere with phosphatase‐based microcystin assays. Currently used agents that interfere with microcystin action, such as inhibitors of ROS
Who reads A Novel Cyanobacterial Nostocyclopeptide is a Potent Antitoxin against Microcystins?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jouni Jokela ; Lars Herfindal ; Matti Wahlsten; Perttu Permi; Frode Selheim ; Vitor Vasconçelos; Stein Ove Døskeland; Kaarina Sivonen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1439-4227)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)