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Microinduction of Buprenorphine/Naloxone: A Review of the Literature by Saeed Ahmed; Siddhi Bhivandkar; Brady B. Lonergan; Joji Suzuki is a Medicine article available to read on EtoBox.

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## Background and objectives: Buprenorphine's high-binding affinity as a partial μ-opioid agonist displaces preexisting full agonists causing precipitated withdrawal, which requires most individuals starting buprenorphine to endure moderate withdrawal prior to induction to avoid precipitated withdrawal. a novel approach called microinduction has emerged to remove this prerequisite. our aim is to review the literature on these alternative approaches. ## Methods: Using keywords including buprenorphine, buprenorphine/naloxone, transdermal buprenorphine, suboxone, microinduction, microdosing, rapid induction, buprenorphine-dosing protocol, the authors searched pubmed/medline, embase, psycinfo, psycharticles, and scopus databases from the date of inception through april 30, 2020, which yielded 1726 results, which, in turn, after manual exclusion for irrelevant content and publication in languages other than english, generated a total of 18 papers. ## Results: On the basis of 18 papers included in this review, 63 patients were successfully transitioned to buprenorphine using different microdosing techniques, primarily in the inpatient setting. from the available data, patients were trans

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Author

Saeed Ahmed; Siddhi Bhivandkar; Brady B. Lonergan; Joji Suzuki

Publisher

Wiley

Published

2020

Language

EN

Field

Medicine (Health Sciences)