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Breast cancers presenting luminal B subtype features show higher discordant human epidermal growth factor receptor 2 results between immunohistochemistry and fluorescence in situ hybridization by Seho Park; Hyung Seok Park; Ja Seung Koo; Woo Ick Yang; Seung Il Kim; Byeong-Woo Park is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND: The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. ## METHODS: Using consecutive tissue microarrays, IHC and FISH were performed as guidelines in 950 invasive breast cancers treated between November 1999 and August 2005. Characteristics and outcomes were retrospectively analyzed using a chi‐square test, the Kaplan‐Meier method, and Cox's model. ## RESULTS: FISH‐positivity was observed in 2.6%, 4.8%, 28.1%, and 93.8% of IHC 0, 1+, 2+, and 3+, respectively, and the concordance rate between the 2 assays was 95.5%. IHC‐positive or FISH‐positive cases were associated with poorer differentiation, negative expression of hormone receptors, and higher proliferative index. Among IHC‐equivocal or IHC‐negative patients, positive FISH was negatively associated with survival in univariate and multivariate analyses. Among IHC‐negative patients, tumors showing luminal B subtype features such as estrogen receptor (ER)‐positive, grade II/III, and high
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- Author
- Seho Park; Hyung Seok Park; Ja Seung Koo; Woo Ick Yang; Seung Il Kim; Byeong-Woo Park
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)