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TH1/TH2 cytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients by J. F. MUñOZ-VALLE; M. VáZQUEZ-DEL MERCADO; T. GARCíA-IGLESIAS; G. OROZCO-BAROCIO; G. BERNARD-MEDINA; G. MARTíNEZ-BONILLA; B. E. BASTIDAS-RAMíREZ; A. D. NAVARRO; M. BUENO; E. MARTíNEZ-LóPEZ; C. R. BEST-AGUILERA; M. KAMACHI; J. ARMENDáRIZ-BORUNDA is a Immunology and Microbiology article available to read on EtoBox.
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## SUMMARY During the course of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), several immune and neuroendocrine changes associated with pregnancy may exert positive (amelioration) or negative (exacerbation) effects on the clinical outcome. In order to shed light on the mechanisms underlying these responses, we performed a prospective longitudinal study in RA and SLE pregnant women, including healthy pregnant women as a control group. Cytokine messenger RNA (mRNA) expression assessed by quantitative competitive polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMC), cytokine levels and lymphocyte proliferation responses (LPR) following phytohaemagglutinin (PHA) stimulation of PBMC, plasma metalloprotease-9 activity (MMP-9) and hormonal status during pregnancy were determined. TNFa was the most abundant cytokine mRNA expressed in PBMC in all groups studied (healthy pregnant women, RA and SLE pregnant patients). However, a general TH2 response reflected by high IL-10 levels was found in RA, as well as SLE, patients. A significant change in IFN-γ was observed in RA patients but only during the first trimester of pregnancy. This compared with a
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It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- J. F. MUñOZ-VALLE; M. VáZQUEZ-DEL MERCADO; T. GARCíA-IGLESIAS; G. OROZCO-BAROCIO; G. BERNARD-MEDINA; G. MARTíNEZ-BONILLA; B. E. BASTIDAS-RAMíREZ; A. D. NAVARRO; M. BUENO; E. MARTíNEZ-LóPEZ; C. R. BEST-AGUILERA; M. KAMACHI; J. ARMENDáRIZ-BORUNDA
- Publisher
- Oxford University Press (OUP)
- Published
- 2003
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)