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Can I read Tubulysin Analogs Incorporating Desmethyl and Dimethyl Tubuphenylalanine Derivatives on EtoBox?
Tubulysin Analogs Incorporating Desmethyl and Dimethyl Tubuphenylalanine Derivatives by Ranganathan Balasubramanian; Bhooma Raghavan; Jaeson C. Steele; Dan L. Sackett; Robert A. Fecik is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tubulysin Analogs Incorporating Desmethyl and Dimethyl Tubuphenylalanine Derivatives about?
A series of tubulysin analogs in which one of the stereogenic centers of tubuphenylalanine was eliminated were synthesized. All compounds were tested for antiproliferative activity towards ovarian cancer cells and for inhibition of tubulin polymerization. The dimethyl analogs were generally more active than the desmethyl analogs, and four analogs have tubulin polymerization IC 50 values similar to combretastatin A4 and the hemiasterlin analog HTI-286.
Who reads Tubulysin Analogs Incorporating Desmethyl and Dimethyl Tubuphenylalanine Derivatives?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ranganathan Balasubramanian; Bhooma Raghavan; Jaeson C. Steele; Dan L. Sackett; Robert A. Fecik
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)